phyllodes tumors are rare, comprising 2.5% of fibroepithelial lesions and 0.3-1% of all primary breast tumors. There may be scattered minute cysts. Periductal stromal tumor: a rare lesion with low-grade sarcomatous behavior. 8600 Rockville Pike Periductal stromal sarcoma in a child: a case report. var sitekey = divs[ j ].getAttribute( 'data-sitekey' ); Kousaka J, Fujii K, Yorozuya K, Mouri Y, Yoshida M, Nakano S, Fukutomi T, Takahashi E, Yokoi T. Breast Cancer. [27] Periductal stromal tumor: a rare lesion with low-grade sarcomatous behavior. Phyllodes Tumor of the Breast Definition Mixed epithelial and stromal/mesenchymal proliferation of breast characterized by increased stromal cellularity and characteristic broad "leaf-like" papillae inserted into cleft-like spaces Alternate/Historical Names Cystosarcoma phyllodes Diagnostic Criteria Usually large and grossly circumscribed Lyon: IARC Press, 2012; 145. break; Phyllodes Tumor of the Breast Definition Mixed epithelial and stromal/mesenchymal proliferation of breast characterized by increased stromal cellularity and characteristic broad "leaf-like" papillae inserted into cleft-like spaces Alternate/Historical Names Cystosarcoma phyllodes Diagnostic Criteria Usually large and grossly circumscribed Fibroadenomas are common benign neoplasms that may be treated conservatively. Accessibility onfinish: function() { //Check the file URL parameter value breast; immunohistochemical stains; periductal stromal sarcoma; periductal stromal tumor; review. Periductal stromal sarcoma: there is a sarcomatous periductal spindle cell proliferation of variable cellularity and atypia around open ducts which lack a phyllodes pattern. DOI: 10.1016/j.path.2017.09.003 Abstract Fibroepithelial breast lesions encompass a heterogeneous group of neoplasms that range from benign to malignant, each exhibiting differing degrees of stromal proliferation in relation to the epithelial compartment. Unlike phyllodes tumors, they do not present with a leaflike architectur In some cases, only cysts are apparent or there may be no distinct gross lesion. Periductal stromal tumor (PDST) is a rare biphasic tumor of the breast that exhibits low-grade malignancy and intermediate behavior. DOI: 10.1016/j.path.2017.09.003 Abstract Fibroepithelial breast lesions encompass a heterogeneous group of neoplasms that range from benign to malignant, each exhibiting differing degrees of stromal proliferation in relation to the epithelial compartment. var divs = forms[ i ].getElementsByTagName( 'div' ); Stromal mitosis and stromal overgrowth are not prominent. [9], Phyllodes tumors are considered to be on a spectrum of disease[10] that consists of fibroadenoma, fibroadenoma variant and benign phyllodes. 2021 Oct 15;11:577227. doi: 10.3389/fonc.2021.577227. Two cases of low-grade periductal stromal sarcoma were classified as benign phyllodes tumors for statistical purposes. The mitotic rate is greater than 3 per 10 HPF. After surgery, the patient received adjuvant chemotherapy. This is a tumour of adult women, usually peri- or post-menopausal (a decade older than the median for phyllodes tumour). { according to the latest world health organization classification of breast tumours, periductal stromal tumors (psts) are to be considered as a rare subtype of phyllodes tumors. 3, 7 the spindle Follow-up information, mode of treatment and previous history of. J Surg Res 2000;94:84-91. The therapeutic management of PSS is based on wide surgery with free margins, and adjuvant therapies are not required. Periductal stromal tumor (PST) is an extremely rare, low-grade neoplasm that arises from breast connective tissue. [citation needed], "Phyllodes Tumor of the Breast: A Clinicopathological Evaluation of 55 Cases", "Phyllodes tumors of the breast: diagnosis, treatment and prognostic factors related to recurrence", "Core Needle Biopsy as a Diagnostic Tool to Differentiate Phyllodes Tumor From Fibroadenoma", "Delayed Conversion of a Fibroadenoma Into a Large Phyllodes Tumor: A Case Report", 10.1002/(SICI)1097-0339(199902)20:2<53::AID-DC1>3.0.CO;2-T, "Phyllodes tumours of the breast: a consensus review", "An adolescent with a phyllodes tumor: A case report and review", "A prospective, multi-institutional study of adjuvant radiotherapy after resection of malignant phyllodes tumors", https://en.wikipedia.org/w/index.php?title=Phyllodes_tumor&oldid=1134450842, This page was last edited on 18 January 2023, at 19:28. stream Phyllodes tumors. Am J Surg Pathol. }; [2] They were previously termed cystosarcoma phyllodes, coined by Johannes Muller in 1838, before being renamed to phyllodes tumor by the World Health Organization in 2003. Phyllodes tumor, also known as cystosarcoma phyllodes, is a rare fibroepithelial tumor of the breast which has some resemblance to a fibroadenoma. An official website of the United States government. . var forms = document.getElementsByTagName( 'form' ); Introduction: Fibroadenomas (FAs) and phyllodes tumors (PTs) are less prevalent but allied to have malignant transformation in many instances. }); <>>> <> WHO classification of tumors of the breast. The site is secure. [14], The common treatment for phyllodes is wide local excision. Rare sites of metastasis, such as to the parotid region, have also been described.[13]. Unlike phyllodes tumors, they do not present with a leaflike architectur Page views in 2022 to date: 72,633. . The case of a 20-year-old female who presented with a lump in her left breast with clinical features mimicking fibroadenoma is reported, which has been recurrence-free for more than 38 months. Core-needle biopsy revealed bilateral breast carcinoma. There may be scattered minute cysts. Periductal stromal sarcoma: usually forms an ill-defined white/grey/tan/yellow mass. 2015 May;23(3):221-4. doi: 10.1177/1066896914567331. [11] Other than surgery, there is no cure for phyllodes, as chemotherapy and radiation therapy are not effective. 2013 Nov;42(11):729-34. An extremely rare entity, the PST is actually classified as a subtype of phyllodes tumor, with specific criteria that are only found upon histological examination of the specimen. endobj soundManager.play(soundID, {onfinish: function() { This site needs JavaScript to work properly. HHS Vulnerability Disclosure, Help Prior to puberty, breasts of both sexes have ducts with variable branching lined by cuboidal epithelium, no lobules and no necrosis; at puberty in females, lobules develop Influenced by estrogens, growth hormone and prolactin but not progesterone Premature thelarche: Onset prior to age 8 in girls with normal BMI in general population Gold Range Silver Metal Detector How To Use, A retrospective search of our Pathology database from 2000 to 2021 identified 6 PST, all evaluated according to the Armed Forces Institute of Pathology (AFIP) criteria. inputs[i].style.display = 'none';//Hide the stop button !BBxHHn%$7Kz{?NC'nH3 @ @ /e2;~63xiyItgo;Nwz%gzo[s]XqZ 7(7J!3Oe|9;0b:CoG1)\(yh x+G_VO(WhzeVpRvG^X:S4~Gg%G~&FdZBZR-26##0":bM0jL'-v{mu~Advy%^pEkHD[Q.VnertD_z]5g')8 ^-+K38l~Arixv4^Gla!}Qhr>7V`BivwlltVi& L.O-=P=ldoCsoLD,!="lG1&qiiSBfGy/m~c(@j'$\M$dRjK/=7( Would you like email updates of new search results? It has biphasic morphology with benign ducts and a sarcomatous stroma with no specific clinical or radiologic findings, which makes it difficult to diagnose (1-4).It was classified as a different entity by the World Health Organization (WHO) in 2002 because of lack . PMID: 30610048 Abstract Periductal stromal hyperplasia is an exceedingly rare biphasic breast tumor with benign ductal elements and spindle-cell stromal proliferation lacking a phyllodes architecture. Macroscopic appearances Periductal stromal sarcoma: usually forms an ill-defined white/grey/tan/yellow mass. Contributed by Joshua J.X. soundManager.play('btnplay_' + ids, { Periductal stromal hyperplasia (PDSH) has been known to present as densities in the breast or vague nodularities, while periductal stromal sarcoma (PDSS) historically presents as a mass, often mimicking fibroadenomas or hamartoma. In one series, 2 of 10 women showed either recurrences or metastases within 12 months: one of these recurred locally with leaf-like formations, suggesting progression to a phyllodes tumour. Garmin Hrm-pro Compatible Apps, Microscopic (optional): Sections show a stromal proliferation in a leaf-like pattern capped by benign ductal epithelium and intact intervening myoepithelial cell layer. document.getElementById('btnplay_' + ids).style.display = 'none'; Periductal stromal tumor (PDST) is a rare biphasic tumor of the breast that exhibits low-grade malignancy and intermediate behavior. Imaging Features of Breast Periductal Stromal Tumor: A Case Report. [Bilateral breast carcinoma. An extremely rare entity, the PST is actually classified as a subtype of phyllodes tumor, with specific criteria that are only found upon histological examination of the specimen. Int J Surg Pathol. [6] In addition, larger masses can stretch the overlying breast tissue leading to nipple retraction, chest wall fixation, and in advanced cases, ulceration from pressure necrosis. 2014 Sep 15;7(10):7042-8. eCollection 2014. params[ 'expired-callback' ] = window[ expired_callback ]; //set the file URL to be an array with the mp3 and ogg file official website and that any information you provide is encrypted xY{PSW 0bj}LCm;unXWhvtGv;n],JRVQ@T% !!B! This site needs JavaScript to work properly. Periductal stromal tumor (PDST) is a rare biphasic tumor of the breast that exhibits low-grade malignancy and intermediate behavior. When severe, mastitis can lead to a breast abscess (5%-11%) or septicemia. [12] The commonest sites for distant metastases are the lung, bone, and abdominal viscera. The mammographic and sonogr [5] On physical examination, the mass can demonstrate a smooth or nodular texture depending on its size. The mammographic and sonographic findings of the palpable mass suggested the possibility of hamartoma. The patient underwent bilateral breast-conserving surgery, including the excision of the large palpable mass in the right breast. Federal government websites often end in .gov or .mil. PubMed Search: Phyllodes tumor of the breast[TI] full text[SB] pathology. J. Periductal stromal tumor: a rare lesion with low-grade sarcomatous behavior. Milk Thistle Concentrated Extract 1000 Mg, PMID: 30610048 Abstract Periductal stromal hyperplasia is an exceedingly rare biphasic breast tumor with benign ductal elements and spindle-cell stromal proliferation lacking a phyllodes architecture. Periductal stromal tumor (PST) of the breast is a rare fibroepithelial neoplasm with controversial pathogenesis. HHS Vulnerability Disclosure, Help Barefoot International Boom Bag, Lyon: IARC Press, 2012; 145. Clipboard, Search History, and several other advanced features are temporarily unavailable. This is about 15 years older than the typical age of patients with fibroadenoma, a condition with which phyllodes tumors may be confused. FOIA Some regard tumors with predominant periductal stromal expansion (i.e., periductal stromal tumor) as a distinct subtype of phyllodes tumor Phyllodes tumor, also known as cystosarcoma phyllodes, is a rare fibroepithelial tumor of the breast which has some resemblance to a fibroadenoma. Page views in 2023 to date: 3,585. . /97EO, xk1*9m ~#oQ}jPNU0 %r# t&NY[6 8}Ed> P!-tsrYTNLYoC k. for ( var i = 0; i < recaptchaWidgets.length; i++ ) { We present a woman aged 50 years who underwent a Tru-cut biopsy for a BI-RADS 4 lesion on her right breast and received a histopathology diagnosis of a fibroadenoma. Anderson Cancer Centre reported the incidence of each as benign (58%), borderline (12%), and malignant (30%). Periductal stromal sarcoma is a low grade malignancy. endstream if ( callback && 'function' == typeof window[ callback ] ) { } endobj Zhonghua Bing Li Xue Za Zhi. The tumor shows infiltrative borders. Keywords: An approximately 5-cm mass was palpated in the upper right breast. periductal stromal tumor breast pathology outlines These rare fibroepithelial lesions display a biphasic morphology, characterized by a cellular stroma surrounding benign ducts. Periductal stromal tumor (PST) is a recently described fibroe-pithelial neoplasm characterized by proliferation of mesenchymal elements growing in a cuffing manner along the bland epithelial structures, presumably ducts. Ann Clin Lab Sci. Synchronous bilateral non-Hodgkin's diffuse large B-cell lymphoma of the breast and left breast invasive ductal carcinoma: a case report and review of literature. [16] The authors of a 2012 study have derived a risk calculator for relapse risk of phyllodes tumors after surgery. Epub 2020 Jun 9. It is distinguished from both fibroadenoma and phyllodes tumour by the lack of any foliated (leaf-like) architecture (hypercellular stroma around distorted epithelial/myoepithelial lined spaces).